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  • Abeta mediates F-actin disassembly in dendritic spines leading to cognitive deficits in Alzheimer's disease.

Abeta mediates F-actin disassembly in dendritic spines leading to cognitive deficits in Alzheimer's disease.

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2018 Jan 31 Others RP Kommaddi, D Das, S Karunakaran… - Journal of …, 2018 - Soc Neuroscience

Full Author : ['Kommaddi, Reddy Peera', 'Das, Debajyoti', 'Karunakaran, Smitha', 'Nanguneri, Siddharth', 'Bapat, Deepti', 'Ray, Ajit', 'Shaw, Eisha', 'Bennett, David A', 'Nair, Deepak', 'Ravindranath, Vijayalakshmi']
Journal Title : The Journal of neuroscience : the official journal of the Society for Neuroscience
Chapter : Section8
Journal Year : 2018
Cited by : 115

Dendritic spine loss is recognized as an early feature of Alzheimer's disease (AD), but the underlying mechanisms are poorly understood. Dendritic spine structure is defined by filamentous actin (F-actin) and we observed depolymerization of synaptosomal F..... Read More

Keywords : ['abeta mediate factin disassembly', 'dendritic spine lead', 'cognitive deficit', 'alzheimer disease']
PubMed Link : https://www.jneurosci.org/content/38/5/1085.abstract
Google Scholar Link : https://scholar.google.com/scholar?cites=4492598906797541327&as_sdt=5,47&sciodt=0,47&hl=en&num=20