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  • TSC1/2 mutations as markers of response to everolimus in metastatic renal cell carcinoma: A case study.

TSC1/2 mutations as markers of response to everolimus in metastatic renal cell carcinoma: A case study.

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2019 Jul-Sep Others Fist_Author_Year_PM

Full Author : ['Jacob, Linu A', 'Shafi, Gowhar']
Journal Title : Indian journal of cancer
Chapter : Section25
Journal Year : 2019

We report a case of a 67-year-old man with pazopanib-resistant metastatic renal cell carcinoma (mRCC) who showed an exceptional response to everolimus. Furthermore, this patient had TSC1 and TSC2 mutations. Only a subset of patients with mRCC respond to mTOR inhibitors and emerging evidences indicate that TSC1 and TSC2 mutations could be markers of response to mTOR inhibition. The current case study supports these accruing evidences......

Keywords : ['metastatic renal cell carcinoma', 'case study', 'response', 'mutation', 'marker', 'everolimus']